Ceftarolin Fosamil CAS:866021-48-9

Name:   Ceftarolin Fosamil

CAS:   866021-48-9

Synonyms:   Ceftaroline
                     Unii-p9vxv1408y
                     Ceftarolin Fosamil
                     Ceftaroline Impurity8
                     Ceftaroline USP/EP/BP
                     Unii-p9vxv1408y USP/EP/BP
                     Ceftaroline Fosamil Acetate Hydrate
                     7R)-2-Carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1
                     acetic acid,(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)

Antimicrobial activity:   A semisynthetic cephalosporin formulated as the water-soluble fosamil acetate prodrug for intravenous administration. Its properties are similar to those of ceftobiprole, with which it shares an enhanced affinity for penicillin-binding protein 2′ (2a) of methicillin-resistant Staph. aureus. It is hydrolyzed by extended-spectrum β-lactamases and is not active against Amp-C derepressed strains of Gram-negative bacilli.

Pharmacokinetics:   Cmax 600 mg intravenous (1-h infusion): 19 mg/L end infusion
                                  Plasma half-life: 2.6 h
                                  Volume of distribution: 0.37 L/kg
                                  Plasma protein binding :<20%
                                  Like ceftobiprole, ceftaroline fosamil is rapidly hydrolyzed in plasma after intravenous infusion and excreted principally in urine. In preliminary clinical studies it appears to be well tolerated.